Discovering New Chemistry and Potential Applications of Metal Tetrapyrroles

Grant number: DP200100178 | Funding period: 2020 - 2023

Completed

Abstract

This project aims to make fundamental advances in inorganic chemistry, coordination chemistry and bioinorganic chemistry by preparing new metal-containing molecules based on specifically designed tetrapyrrole ligands. Innovative synthetic methods will be developed to enable systematic chemical modifications to explore the chemical and biological properties of the metal complexes. The potential of the new molecules to be of use as tracers for molecular imaging will be investigated. An expected outcome of this research will be an increased understanding of how chemical properties dictate the biological activity of metal complexes informing the potential long-term translation of this chemistry ..

View full description

Related publications (2)

Cu(ATSM) Increases P-Glycoprotein Expression and Function at the Blood-Brain Barrier in C57BL6/J Mice

J Pyun, HJ Koay, P Runwal, C Mawal, AI Bush, Y Pan, PS Donnelly, JL Short, JA Nicolazzo

2023-08-01

P-glycoprotein (P-gp), expressed at the blood-brain barrier (BBB), is critical in preventing brain access to substrate drugs and e..

Novel Anti-Neuroinflammatory Properties of a Thiosemicarbazone–Pyridylhydrazone Copper(II) Complex

XY Choo, LE McInnes, A Grubman, JM Wasielewska, I Belaya, E Burrows, H Quek, JC Martín, S Loppi, A Sorvari, D Rait, A Powell, C Duncan, JR Liddell, H Tanila, JM Polo, T Malm, KM Kanninen, PS Donnelly, AR White

2022-09-01

Neuroinflammation has a major role in several brain disorders including Alzheimer’s disease (AD), yet at present there are no effe..

University of Melbourne Researchers

Paul Donnelly